Scientists to create human-rabbit embryos
Scientists are poised to press ahead with controversial plans to create hybrid human and rabbit embryos. It emerged yesterday that three British teams - including one led by Professor Ian Wilmut at Edinburgh University - are due this month to seek licences from the Human Fertilisation and Embryology Authority allowing them to create embryos that are 99.9 per cent human and 0.1 per cent rabbit. The scientists are also looking at the possibility of creating similar "chimera" embryos by mixing human and cow genes. The aim is to find a ready source of "human" embryonic stem cells without the ethical problems of tampering with human life. Making the chimeras would involve removing the nuclei from animal eggs and replacing them with genetic material taken from human cells. The embryos would be mostly human, but would contain animal genes as there are genes outside the nucleus that sit within tiny rod-like powerplants in the cell called mitochondria. These structures, which supply energy, would remain in the animal eggs after the nuclear transfer of human DNA.
Professor Stephen Minger, of King's College London, who leads one of the groups, wants to use stem cells extracted from the embryos to investigate human neurological diseases. "The idea is to gain information that we can't get from animal models," he said."We want to create tools we can use in academic and pharmaceutical research. We want to create disease-specific cell lines - predominantly neurological disorders with a known genetic basis, such as Alzheimer's and Parkinson's disease. It could lead to new therapies."
Scientists are poised to press ahead with controversial plans to create hybrid human and rabbit embryos. It emerged yesterday that three British teams - including one led by Professor Ian Wilmut at Edinburgh University - are due this month to seek licences from the Human Fertilisation and Embryology Authority allowing them to create embryos that are 99.9 per cent human and 0.1 per cent rabbit. The scientists are also looking at the possibility of creating similar "chimera" embryos by mixing human and cow genes. The aim is to find a ready source of "human" embryonic stem cells without the ethical problems of tampering with human life. Making the chimeras would involve removing the nuclei from animal eggs and replacing them with genetic material taken from human cells. The embryos would be mostly human, but would contain animal genes as there are genes outside the nucleus that sit within tiny rod-like powerplants in the cell called mitochondria. These structures, which supply energy, would remain in the animal eggs after the nuclear transfer of human DNA.
Professor Stephen Minger, of King's College London, who leads one of the groups, wants to use stem cells extracted from the embryos to investigate human neurological diseases. "The idea is to gain information that we can't get from animal models," he said."We want to create tools we can use in academic and pharmaceutical research. We want to create disease-specific cell lines - predominantly neurological disorders with a known genetic basis, such as Alzheimer's and Parkinson's disease. It could lead to new therapies."

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